Drug Elimination and Clearence

Drugs are removed from the body by various elimination processes. Drug elimination refers to the irreversible removal of drug from the body by all routes of elimination. The declining plasma drug concentration observed after systemic drug absorption shows that the drug is being eliminated from the body but does not indicate which elimination processes is involved. Drug elimination is usually divided into two major components: excretion and biotransformation. Drug excretion is the removal of the intact drug. Non-volatile drugs are excreted mainly by renal excretion, a process in which the drug passes through the kidney to the bladder and ultimately into the urine. Drug elimination in the body involves many complex rate processes. Although organ systems have specific functions, the tissues within the organs are not structurally homogeneous, and elimination processes may vary in each organ, drug elimination was modelled by an overall first-order elimination rate process. Clearance may be defined as the volume of fluid cleared of drug from the body per unit of time.

 

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